Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.52 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16763403 | 0.92 | HCAR3 (0.47) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL15428361 | 0.92 | HCAR3 (0.47) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL16485897 | 0.92 | HCAR3 (0.47) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL2728614 | 0.89 | HCAR3 (0.64) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL16485919 | 0.86 | L3MBTL1 (0.50) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL7541568 | 0.85 | HCAR3 (0.64) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL22716728 | 0.84 | HCAR3 (0.52) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL31192527 | 0.84 | HCAR3 (0.52) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL17675674 | 0.83 | HCAR3 (0.55) | HCAR3WNK1L3MBTL1MAPTMAPK1 | |
| SCHEMBL22724894 | 0.83 | MAPK1 (0.52) | HCAR3WNK1L3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670211-B2 | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2017-06-06 | — | — | US | disclosed |
| EP-3033341-B1 | NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2017-05-03 | — | — | EP | disclosed |