SCHEMBL18808272

SCHEMBL18808272

C=CC(=O)Oc1ccc(-c2ccc(OC)c(F)c2)cc1F

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.51
RAB9A P51151 2/20 0.47
LMNA P02545 1/20 0.47
MAPK1 P28482 1/20 0.47
HTT P42858 1/20 0.47
FFAR1 O14842 1/20 0.44
CYP17A1 P05093 1/20 0.43
AR P10275 1/20 0.43
PTGS2 P35354 5/20 0.43
PDGFRB P09619 1/20 0.43
PDGFRA P16234 1/20 0.43
TDP2 O95551 1/20 0.42
ABHD6 Q9BV23 1/20 0.42
PTGS1 P23219 2/20 0.42
NAAA Q02083 1/20 0.41
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20312065 0.98 ERN1 (0.50) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL9607776 0.92 ERN1 (0.40) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL18472700 0.91 ERN1 (0.49) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL20312020 0.91 ERN1 (0.49) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL17547403 0.87 ERN1 (0.38) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL16803332 0.87 MAPT (0.42) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL21417666 0.86 AR (0.41) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL19882317 0.86 AR (0.44) ERN1RAB9ALMNAMAPK1HTT
SCHEMBL9613625 0.86 THRB (0.43) ERN1LMNAMAPK1FFAR1
SCHEMBL2604655 0.86 TYMS (0.41) ERN1MAPK1FFAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3551723-B1 ADDITIVES FOR LIQUID CRYSTAL MIXTURES MERCK PATENT GMBH (DE) 2023-09-20 EP disclosed
EP-3933009-B1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-08-16 EP disclosed
EP-3628721-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-03-01 EP disclosed
EP-3944011-A1 LIQUID-CRYSTAL DISPLAY Merck Patent GmbH (DE) 2022-01-26 EP disclosed
EP-3933009-A1 LIQUID CRYSTAL MEDIUM Merck Patent GmbH (DE) 2022-01-05 EP disclosed
EP-3257916-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2021-11-17 EP disclosed
EP-3688118-B1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2021-05-19 EP disclosed
EP-3521401-B1 COMPOUNDS FOR HOMEOTROPIC ALIGNMENT OF LIQUID CRYSTALINE MEDIA MERCK PATENT GMBH (DE) 2021-04-21 EP disclosed
EP-3587536-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2021-03-24 EP disclosed
EP-3757192-A1 LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2020-12-30 EP disclosed
EP-3292181-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2019-09-11 EP disclosed
EP-3521401-A1 COMPOUNDS FOR HOMEOTROPIC ALIGNMENT OF LIQUID CRYSTALINE MEDIA Merck Patent GmbH (DE) 2019-08-07 EP disclosed
EP-3502209-A1 LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT Merck Patent GmbH (DE) 2019-06-26 EP disclosed
EP-2886627-B1 Liquid crystalline medium MERCK PATENT GMBH (DE) 2019-05-15 EP disclosed
EP-2990460-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-04-03 EP disclosed
EP-2985334-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2018-06-20 EP disclosed
EP-3323872-A1 COMPOUNDS FOR HOMOTROPIC ALIGNMENT OF LIQUID CRYSTAL MEDIA Merck Patent GmbH (DE) 2018-05-23 EP disclosed
EP-3083408-B1 FILLING DEVICE AND USE THEREOF FOR FILLING A FLUID MERCK PATENT GMBH (DE) 2018-02-21 EP disclosed
EP-2691490-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-07-26 EP disclosed
EP-3162875-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS Merck Patent GmbH (DE) 2017-05-03 EP disclosed