Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 8/20 | 0.50 |
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18808350 | 0.89 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL18808348 | 0.83 | NPC1 (0.52) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL18808331 | 0.82 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL18808332 | 0.82 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL18808492 | 0.81 | KCNQ3 (0.43) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL22453429 | 0.80 | LRRK2 (0.42) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL27273150 | 0.75 | PRKCI (0.40) | MAPTKDM4EMAPK1 | |
| SCHEMBL18808329 | 0.74 | MAPT (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL22453825 | 0.74 | HDAC3 (0.45) | NPC1RAB9AKMT2AMAPTPOLB | |
| SCHEMBL19936703 | 0.73 | HCAR3 (0.51) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964219-B1 | SUBSTITUTED INDAZOLE OR INDOLE DERIVATIVES AS IN VITRO MAO-B INHIBITORS | NTZ LAB LTD (BG) | 2017-05-03 | — | — | EP | disclosed |