Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM2 | P50570 | 2/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472394 | 0.81 | CYP1A2 (0.47) | DNM2HCAR3KMOKDM4DKDM4E | |
| SCHEMBL13472364 | 0.80 | KDM4D (0.57) | DNM2HCAR3KMOKDM4DKDM4E | |
| SCHEMBL13472391 | 0.78 | SMN1; SMN2 (0.43) | DNM2HCAR3KMOKDM4DKDM4E | |
| SCHEMBL13472396 | 0.78 | DNM2 (0.44) | DNM2HCAR3KMOKDM4DKDM4E | |
| SCHEMBL13472374 | 0.78 | DNM2 (0.52) | DNM2KMOKDM4DKDM4EALDH1A1 | |
| SCHEMBL13472370 | 0.78 | KMO (0.48) | HCAR3KMOHCAR2 | |
| SCHEMBL13472375 | 0.76 | KMO (0.47) | KMOKDM4DKDM4E | |
| SCHEMBL13472365 | 0.76 | KMO (0.47) | KMOKDM4DMAP4K4CLK4 | |
| SCHEMBL13472404 | 0.74 | STK17B (0.49) | — | |
| SCHEMBL13472590 | 0.74 | CYP1A2 (0.55) | KMOKDM4DKDM4ECLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167489-B1 | PYRIMIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2017-05-03 | — | — | EP | disclosed |