Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | AGER | Q15109 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11284703 | 0.87 | NAPRT (0.56) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL5073420 | 0.83 | SMN1; SMN2 (0.43) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL5252687 | 0.82 | KDM4E (0.59) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL3880000 | 0.82 | KDM4E (0.59) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL123202 | 0.81 | KDM4E (0.57) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL3931891 | 0.81 | NAPRT (0.58) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL242926 | 0.81 | SMN1; SMN2 (0.58) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL2782918 | 0.81 | KDM4E (0.62) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL14515519 | 0.81 | KDM4E (0.57) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL2300950 | 0.81 | NAPRT (0.58) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090117032-A1 | Imaging Agents for Early Detection and Monitoring of Cardiovascular Plaque | THE GENERAL HOSPITAL CORPORATION (US) | 2009-05-07 | — | — | US | claimed |
| EP-1011738-A1 | IMAGING AGENTS FOR EARLY DETECTION OF CARDIOVASCULAR PLAQUE | THE GENERAL HOSPITAL CORPORATION (US) | 2000-06-28 | — | — | EP | claimed |
| WO-1999012579-A1 | IMAGING AGENTS FOR EARLY DETECTION AND MONITORING OF CARDIOVASCULAR PLAQUE | THE GENERAL HOSPITAL CORPORATION (US) | 1999-03-18 | — | — | WO | claimed |
| US-20210338849-A1 | COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-11-04 | — | — | US | disclosed |
| EP-3231804-B1 | COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-03-03 | — | — | EP | disclosed |
| US-10857247-B2 | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders | THE GENERAL HOSPITAL CORPORATION (US) | 2020-12-08 | — | — | US | disclosed |
| US-20190261858-A1 | IMAGING METHOD FOR ACUTE LYMPHOBLASTIC LEUKEMIA USING AN IMAGING AGENT AND METHOD OF PRODUCING AN IMAGING AGENT | SATZ STANLEY (US) | 2019-08-29 | — | — | US | disclosed |
| US-10300154-B2 | Anticoagulant derivatives for cardiovascular imaging | ELMALEH DAVID R (US) | 2019-05-28 | — | — | US | disclosed |
| EP-3231804-A1 | COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS | The General Hospital Corporation (US) | 2017-10-18 | — | — | EP | disclosed |
| US-20170290931-A1 | ANTICOAGULANT DERIVATIVES FOR CARDIOVASCULAR IMAGING | ELMALEH DAVID R (US) | 2017-10-12 | — | — | US | disclosed |
| EP-2268647-B1 | COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS | MASSACHUSETTS GEN HOSPITAL (US) | 2017-01-25 | — | — | EP | disclosed |
| WO-1998048849-A1 | RADIONUCLIDE ASSOCIATED WITH NUCLEOTIDE POLYPHOSPHATE AS TUMOR IMAGING AGENTS | THE GENERAL HOSPITAL CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |
| US-5824670-A | ANTIINFLAMMATORY AGENTS; TREATING DERMATOSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-10-20 | — | — | US | disclosed |
| EP-0869820-A1 | CARDIOVASCULAR AND THROMBUS IMAGING AGENTS, METHODS AND KITS | THE GENERAL HOSPITAL CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024146-A9 | CARDIOVASCULAR AND THROMBUS IMAGING AGENTS, METHODS AND KITS | — | 1997-10-16 | — | — | WO | disclosed |
| WO-1997024146-A1 | CARDIOVASCULAR AND THROMBUS IMAGING AGENTS, METHODS AND KITS | THE GENERAL HOSPITAL CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |
| US-5608093-A | ANTIINFLAMMATORY AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |
| EP-0708111-A1 | 17-Desoxy corticosteroid-21-esters, a process for their preparation and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-24 | — | — | EP | disclosed |
| EP-0646593-A1 | Corticoid-17,21-dicarboxylic acid ester and corticosteroid-17-carboxylic acid ester-21-carbonic, process for their production and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-05 | — | — | EP | disclosed |
| EP-0640616-A2 | 17-Alkylcarbonate, 21-0-carbonic/carboxylic acid esters of corticosteroids, a method for their production and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338849-A1 | COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS | APP, PSEN1, PSEN2 | NAPRT 862/4885KDM4E 3295/4885TDP1 1128/4885 |
| US-10300154-B2 | Anticoagulant derivatives for cardiovascular imaging | F3, TFPI, SERPINC1 | NAPRT 2290/4885KDM4E 2306/4885TDP1 1442/4885 |
| US-10857247-B2 | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders | APP, PSEN1, PSEN2 | NAPRT 862/4885KDM4E 3295/4885TDP1 1128/4885 |
| US-20170290931-A1 | ANTICOAGULANT DERIVATIVES FOR CARDIOVASCULAR IMAGING | F3, TFPI, SERPINC1 | NAPRT 2290/4885KDM4E 2306/4885TDP1 1442/4885 |
| US-20190261858-A1 | IMAGING METHOD FOR ACUTE LYMPHOBLASTIC LEUKEMIA USING AN IMAGING AGENT AND METHOD OF PRODUCING AN IMAGING AGENT | MCL1, FLI1, BCL3 | NAPRT 1911/4885KDM4E 2860/4885TDP1 1630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.