Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12497252 | 0.87 | HTR2C (0.46) | CCNA2CDK2CCNA1AURKAMAPK1 | |
| SCHEMBL18819044 | 0.81 | ALDH1A1 (0.41) | MAPK1GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL18819049 | 0.81 | MKNK1 (0.41) | MKNK1MKNK2HRH4 | |
| SCHEMBL18818984 | 0.81 | KCNH3 (0.38) | MAPK1MEN1KMT2AMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL28405121 | 0.80 | KCNH3 (0.38) | MAPK1MEN1KMT2AMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL28410680 | 0.79 | ALDH1A1 (0.40) | MAPK1GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL18818561 | 0.78 | PIK3CD (0.36) | CCNA2CDK2HRH4 | |
| SCHEMBL18818988 | 0.77 | HRH4 (0.44) | MAPK1TYRO3MERTKFLT3GAS6 | |
| SCHEMBL3279091 | 0.76 | CCNA2 (0.35) | CCNA2CDK2CCNA1AURKAMAPK1 | |
| SCHEMBL8195609 | 0.75 | HTR2C (0.34) | CCNA2CDK2MERTKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428762-B | Phthalazinone derivatives, preparation method and use thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| WO-2017071636-A1 | PHTHALAZINE KETONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-05-04 | — | — | WO | disclosed |