Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 19/20 | 1.00 |
| ▸ | HCAR3 | P49019 | 12/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acifran SCHEMBL5055334 | 1.00 | HCAR2 (1.00) | HCAR2HCAR3CYP1A2 | |
| Acifran SCHEMBL1876828 | 0.91 | HCAR2 (0.83) | HCAR2HCAR3CYP1A2 | |
| Acifran SCHEMBL11406401 | 0.89 | HCAR2 (0.78) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL13537488 | 0.87 | HCAR2 (0.77) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3108561 | 0.87 | HCAR2 (0.76) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3110269 | 0.85 | HCAR2 (1.00) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL11297109 | 0.85 | HCAR2 (0.74) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3098180 | 0.85 | HCAR2 (1.00) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL11293467 | 0.84 | HCAR2 (0.72) | HCAR2HCAR3CYP1A2 | |
| SCHEMBL3108555 | 0.84 | HCAR2 (1.00) | HCAR2HCAR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3306 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076956-A1 | METHODS FOR REGRESSING OR REVERSING FIBROSIS AND/OR LIVER CIRRHOSIS IN A SUBJECT IN NEED THEREOF USING HIGH-DOSE NIACIN, OR A NIACIN ANALOG THEREOF | US GOV VETERANS AFFAIRS (US) | 2026-03-19 | — | — | US | claimed |
| EP-4243822-A1 | USE OF PHARMACEUTICAL DOSES OF NIACIN, OR AN ANALOG THEREOF, FOR THE REGRESSION OR REVERSAL OF FIBROSIS AND/OR LIVER CIRRHOSIS | The Regents of The University of California (US) | 2023-09-20 | — | — | EP | claimed |
| WO-2022104289-A1 | USE OF PHARMACEUTICAL DOSES OF NIACIN, OR AN ANALOG THEREOF, FOR THE REGRESSION OR REVERSAL OF FIBROSIS AND/OR LIVER CIRRHOSIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-05-19 | — | — | WO | claimed |
| US-20220152012-A1 | METHODS FOR REGRESSING OR REVERSING FIBROSIS AND/OR LIVER CIRRHOSIS IN A SUBJECT IN NEED THEREOF USING HIGH-DOSE NIACIN, OR A NIACIN ANALOG THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-05-19 | — | — | US | claimed |
| CN-114144174-A | Methods and compositions for supporting kidney health | 加利福尼亚大学董事会 | 2022-03-04 | — | — | CN | claimed |
| EP-3937920-A1 | METHODS AND COMPOSITIONS FOR SUPPORTING RENAL HEALTH | The Regents of the University of California (US) | 2022-01-19 | — | — | EP | claimed |
| WO-2020186154-A1 | METHODS AND COMPOSITIONS FOR SUPPORTING RENAL HEALTH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-09-17 | — | — | WO | claimed |
| CN-107243078-A | Make proprotein convertases subtilisin/types of KEXIN 9（PCSK9）The method of reduction | 克塔巴西斯制药有限公司 | 2017-10-13 | — | — | CN | claimed |
| US-20160367645-A1 | LYSOSOMAL ACID LIPASE THERAPY FOR NAFLD AND RELATED DISEASES | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2016-12-22 | — | — | US | claimed |
| US-20150352094-A1 | USE OF FATTY ACID NIACIN CONJUGATES FOR TREATING DISEASES | CATABASIS PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | claimed |
| WO-2000069445-A1 | COMBINATION THERAPY FOR TREATING HYPERCHOLESTEROLEMIA | GELTEX PHARMACEUTICALS, INC. (US) | 2000-11-23 | — | — | WO | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| WO-1998022114-A1 | A METHOD FOR PROMOTING TISSUE REPAIR | DUMEX-ALPHARMA A/S (DK) | 1998-05-28 | — | — | WO | claimed |
| US-5260305-A | Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination | E. R. SQUIBB & SONS, INC. (US) | 1993-11-09 | — | — | US | claimed |
| US-5179097-A | Salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids | ANGRES ISAAC A (US) | 1993-01-12 | — | — | US | claimed |
| US-4933184-A | Menthol enhancement of transdermal drug delivery | AMERICAN HOME PRODUCTS CORP. (DEL) (US) | 1990-06-12 | — | — | US | claimed |
| EP-0006305-B1 | DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID, ESPECIALLY FOR USE AS HYPOLIPIDEMIC AGENTS, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, TETRAHYDROPYRAN-2,3,5-TRIONES USEFUL IN THE PREPARATION OF THE SAID DERIVATIVES AND A PROCESS FOR PREPARING THESE TETRAHYDROPYRAN-2,3,5-TRIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-08-11 | — | — | EP | claimed |
| US-4244958-A | Hypolipidemic derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | claimed |
| WO-1980000025-A1 | DERIVATIVES OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID,PREPARATIONS AND USE THEREOF AND TETRAHYDROPYRAN-2,3,5-TRIONE INTERMEDIATES | AMERICAN HOME PROD (US) | 1980-01-10 | — | — | WO | claimed |
| EP-0006305-A1 | Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-09 | — | — | EP | claimed |