Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.40 |
| ▸ | RARB | P10826 | 6/20 | 0.40 |
| ▸ | RARG | P13631 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | RXRB | P28702 | 3/20 | 0.36 |
| ▸ | RXRG | P48443 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365634 | 0.86 | RXRA (0.42) | RXRARARBRARGHTR2AHTR2C | |
| SCHEMBL8362259 | 0.86 | RXRA (0.42) | RXRARARBRARGHTR2AHTR2C | |
| SCHEMBL8362255 | 0.86 | RXRA (0.42) | RXRARARBRARGHTR2AHTR2C | |
| SCHEMBL18573596 | 0.80 | RXRA (0.43) | RXRARARBRARGRARARXRB | |
| SCHEMBL19423206 | 0.79 | RXRA (0.38) | RXRARARBRARGHTR2AHTR2C | |
| SCHEMBL8364733 | 0.73 | RXRA (0.47) | RXRARARBRARGRARARXRB | |
| SCHEMBL8366248 | 0.73 | RXRA (0.47) | RXRARARBRARGRARARXRB | |
| SCHEMBL7503006 | 0.73 | RXRA (0.47) | RXRARARBRARGRARARXRB | |
| SCHEMBL7567313 | 0.73 | RXRA (0.50) | RXRARARBRARGRARARXRB | |
| SCHEMBL9183823 | 0.73 | RARB (0.45) | RXRARARBRARGRARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017155578-A1 | TREATMENT OF MUSCULAR DISORDERS WITH COMBINATIONS OF RXR AGONISTS AND THYROID HORMONES | Io Therapeutics, Inc. (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017075612-A1 | TREATMENT OF CANCER WITH COMBINATIONS OF RXR AGONISTS AND THYROID HORMONES | Io Therapeutics, Inc. (US) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017075607-A1 | TREATMENT OF NERVOUS SYSTEM DISORDERS USING COMBINATIONS OF PXR AGONISTS AND THYROID HORMONES | Io Therapeutics, Inc. (US) | 2017-05-04 | — | — | WO | disclosed |