Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 15/20 | 0.54 |
| ▸ | MTOR | P42345 | 11/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824924 | 0.96 | ATM (0.59) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL18824834 | 0.91 | ATM (0.46) | ATMMTORPIK3CAATRADORA3 | |
| SCHEMBL18824692 | 0.90 | ATM (0.48) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17241726 | 0.87 | ATM (0.61) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL18824775 | 0.85 | ATM (0.52) | ATMMTORPIK3CAKCNH2 | |
| SCHEMBL17241494 | 0.83 | ATM (0.62) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17241779 | 0.83 | ATM (0.62) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17241434 | 0.82 | ATM (0.60) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17241426 | 0.80 | MTOR (0.61) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL18824763 | 0.79 | ATM (0.47) | ATMMTORPIK3CAKCNH2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |