Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 7/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824692 | 0.92 | ATM (0.48) | ATMATRADORA2AADORA1ADORA3 | |
| SCHEMBL18824583 | 0.91 | ATM (0.54) | ATMATRADORA2AADORA1ADORA3 | |
| SCHEMBL18824924 | 0.87 | ATM (0.59) | ATMATRPDE3BPDE3AP2RY12 | |
| SCHEMBL17241366 | 0.86 | ATM (0.59) | ATMATRPIK3CAMTOR | |
| SCHEMBL18824690 | 0.83 | ATM (0.52) | ATMATRADORA2AADORA1ADORA3 | |
| SCHEMBL17241472 | 0.81 | ATM (0.60) | ATMATRPIK3CAMTOR | |
| SCHEMBL18824763 | 0.81 | ATM (0.47) | ATMADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL18824685 | 0.80 | ATM (0.49) | ATMATRPIK3CAMTOR | |
| SCHEMBL18824923 | 0.80 | ATM (0.47) | ATMATRPIK3CAMTOR | |
| SCHEMBL18824672 | 0.79 | ATM (0.57) | ATMATRADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | claimed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | claimed |