Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 14/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.43 |
| ▸ | MTOR | P42345 | 10/20 | 0.43 |
| ▸ | ATR | Q13535 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824834 | 0.92 | ATM (0.46) | ATMPIK3CAMTORATRADORA3 | |
| SCHEMBL18824583 | 0.90 | ATM (0.54) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL18824763 | 0.88 | ATM (0.47) | ATMPIK3CAMTORADORA3ADORA2A | |
| SCHEMBL18824924 | 0.86 | ATM (0.59) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17241432 | 0.86 | ATM (0.61) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL18824627 | 0.84 | ATM (0.51) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17241449 | 0.82 | ATM (0.62) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL17241434 | 0.82 | ATM (0.60) | ATMPIK3CAMTORATRPIK3CD | |
| SCHEMBL18824690 | 0.81 | ATM (0.52) | ATMATRADORA3ADORA2AADORA2B | |
| SCHEMBL17241436 | 0.80 | ATM (0.41) | ATMPIK3CAMTORATRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | claimed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | claimed |
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |