Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 7/20 | 0.51 |
| ▸ | MTOR | P42345 | 6/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.51 |
| ▸ | ATR | Q13535 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 3/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824923 | 0.94 | ATM (0.47) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL18824685 | 0.93 | ATM (0.49) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17241465 | 0.80 | ATM (0.60) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17241387 | 0.79 | ATM (0.61) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL18824834 | 0.77 | ATM (0.46) | ATMMTORPIK3CAATRGPR119 | |
| SCHEMBL17241559 | 0.76 | ATM (0.61) | ATMMTORPIK3CAATRKCNH2 | |
| Trifluoroacetic Acid SCHEMBL17241751 | 0.75 | ATM (0.56) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL18824656 | 0.75 | ATM (0.38) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL20550140 | 0.75 | ATM (0.82) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL20550139 | 0.75 | ATM (0.82) | ATMMTORPIK3CAATRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | claimed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | claimed |
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |