Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 16/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 7/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824730 | 0.90 | ATM (0.38) | ATMKCNH2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17241384 | 0.90 | ATM (0.45) | ATMKCNH2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL18824763 | 0.84 | ATM (0.47) | ATMKCNH2MTORPIK3CA | |
| SCHEMBL18824627 | 0.84 | ATM (0.51) | ATMKCNH2MTORPIK3CAATR | |
| SCHEMBL18824719 | 0.82 | IRAK4 (0.34) | ATMKCNH2PIK3CA | |
| SCHEMBL17241609 | 0.81 | ATM (0.63) | ATMMTORPIK3CAATR | |
| SCHEMBL17241430 | 0.80 | ATM (0.64) | ATMKCNH2MTORPIK3CAATR | |
| SCHEMBL17241367 | 0.80 | ATM (0.43) | ATMKCNH2MTORPIK3CAATR | |
| SCHEMBL17241436 | 0.78 | ATM (0.41) | ATMKCNH2MTORPIK3CAATR | |
| SCHEMBL17241473 | 0.76 | CASP3 (0.36) | ATMPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |