Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 18/20 | 0.41 |
| ▸ | ATR | Q13535 | 11/20 | 0.41 |
| ▸ | MTOR | P42345 | 11/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17241384 | 0.89 | ATM (0.45) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL18824950 | 0.83 | ATM (0.48) | ATMATRMTORPIK3CA | |
| SCHEMBL17241432 | 0.82 | ATM (0.61) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL17241466 | 0.82 | ATM (0.61) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL17241473 | 0.81 | CASP3 (0.36) | ATMPIK3CAPIK3CBPIK3CDBRD4 | |
| SCHEMBL18824692 | 0.80 | ATM (0.48) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL17241367 | 0.79 | ATM (0.43) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL18641733 | 0.78 | ATM (0.42) | ATMATRMTORPIK3CAPIK3CD | |
| SCHEMBL18824735 | 0.78 | ATM (0.42) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL17241434 | 0.77 | ATM (0.60) | ATMATRMTORPIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3370722-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |
| WO-2017076898-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |
| EP-3140303-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2017-03-15 | — | — | EP | disclosed |
| WO-2015170081-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2015-11-12 | — | — | WO | disclosed |