Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.53 |
| ▸ | HPD | P32754 | 6/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8753959 | 0.87 | MRGPRX4 (0.57) | MRGPRX4ADRB2ADRB1HTR1AADRB3 | |
| SCHEMBL6121759 | 0.87 | MRGPRX4 (0.54) | MRGPRX4HPDADRB2ADRB1HTR1A | |
| SCHEMBL31318410 | 0.73 | MRGPRX4 (0.74) | MRGPRX4HPDADRB2ADRB1HTR1A | |
| SCHEMBL5101144 | 0.73 | MRGPRX4 (0.74) | MRGPRX4HPDADRB2ADRB1HTR1A | |
| SCHEMBL19883576 | 0.73 | MRGPRX4 (0.54) | MRGPRX4HPDADRB2ADRB1HTR1A | |
| SCHEMBL28349971 | 0.73 | MRGPRX4 (0.59) | MRGPRX4SLC6A4MAOAMAOBABCB1 | |
| SCHEMBL5270656 | 0.71 | MRGPRX4 (0.56) | MRGPRX4ADRB2ADRB1HTR1AADRB3 | |
| SCHEMBL17702832 | 0.69 | GAA (0.39) | MRGPRX4HPDTSHRMAOAMAOB | |
| SCHEMBL5343062 | 0.69 | HPGD (0.47) | MRGPRX4HPDADRB2ADRB1HTR1A | |
| SCHEMBL22480543 | 0.69 | MRGPRX4 (1.00) | MRGPRX4PTGER1HPGDRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640719-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-05-10 | — | — | EP | disclosed |