Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830084 | 0.89 | MAPK6 (0.45) | MAPK6CDK2CDK1CDK4CCND1 | |
| SCHEMBL18830599 | 0.87 | MAPK6 (0.44) | MAPK6 | |
| SCHEMBL18830031 | 0.85 | MAPK6 (0.42) | MAPK6SYK | |
| SCHEMBL18830394 | 0.84 | MAPK6 (0.43) | MAPK6CDK2CDK1CDK4CCND1 | |
| SCHEMBL18830434 | 0.84 | MAPK6 (0.52) | MAPK6CDK2SYK | |
| SCHEMBL18830273 | 0.84 | MAPK6 (0.40) | MAPK6CDK2SYKCCNA2CCNA1 | |
| SCHEMBL18830090 | 0.84 | SYK (0.44) | MAPK6CDK2SYKCCNA2CCNA1 | |
| SCHEMBL18830136 | 0.84 | SYK (0.42) | MAPK6CDK2SYKCCNA2CCNA1 | |
| SCHEMBL18830094 | 0.83 | CDK1 (0.46) | MAPK6CDK2CDK1CDK4CCND1 | |
| SCHEMBL18830167 | 0.83 | MAPK6 (0.42) | MAPK6SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |