Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830599 | 0.87 | MAPK6 (0.44) | MAPK6MERTK | |
| SCHEMBL18830434 | 0.85 | MAPK6 (0.52) | MAPK6SYKCDK2CDK9MERTK | |
| SCHEMBL18830090 | 0.85 | SYK (0.44) | MAPK6SYKCDK2MERTK | |
| SCHEMBL18830136 | 0.85 | SYK (0.42) | MAPK6SYKCDK2MERTK | |
| SCHEMBL18830031 | 0.85 | MAPK6 (0.42) | MAPK6SYKMERTK | |
| SCHEMBL18830167 | 0.84 | MAPK6 (0.42) | MAPK6SYKADORA2A | |
| SCHEMBL18830135 | 0.84 | MAPK6 (0.47) | MAPK6SYKCDK1CDK4CCND1 | |
| SCHEMBL18830257 | 0.84 | MEN1 (0.43) | MAPK6SYKCDK2MERTK | |
| SCHEMBL18830273 | 0.83 | MAPK6 (0.40) | MAPK6SYKCDK2 | |
| SCHEMBL18830059 | 0.82 | MAPK1 (0.43) | MAPK6SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |