Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
| ▸ | YAP1 | P46937 | 1/20 | 0.34 |
| ▸ | ESRRA | P11474 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15731226 | 0.88 | NOTUM (0.40) | NOTUMCFTRGPR35GUSBYAP1 | |
| SCHEMBL15731227 | 0.88 | NOTUM (0.40) | NOTUMCFTRGPR35GUSBYAP1 | |
| SCHEMBL13280371 | 0.83 | YAP1 (0.49) | NOTUMCFTRGPR35YAP1KDM4E | |
| SCHEMBL15731225 | 0.82 | MAPK1 (0.41) | NOTUMCFTRGPR35GUSBYAP1 | |
| SCHEMBL15700382 | 0.82 | EZH2 (0.38) | NOTUMYAP1CHEK1CHEK2ALDH1A1 | |
| SCHEMBL18830151 | 0.82 | YAP1 (0.51) | NOTUMCFTRGPR35YAP1KDM4E | |
| SCHEMBL15710246 | 0.78 | KMT2A (0.41) | KDM4EMAPK1KMT2A | |
| SCHEMBL13280467 | 0.78 | KMT2A (0.41) | KDM4EMAPK1KMT2A | |
| SCHEMBL13280469 | 0.78 | KMT2A (0.41) | KDM4EMAPK1KMT2A | |
| SCHEMBL13280057 | 0.77 | RHOA (0.38) | NOTUMCFTRGPR35YAP1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |