Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 1/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13280371 | 0.99 | YAP1 (0.49) | YAP1RIPK1GPR35NOTUMKDM4E | |
| SCHEMBL15731225 | 0.88 | MAPK1 (0.41) | YAP1GPR35NOTUMCFTREPHX2 | |
| SCHEMBL13280057 | 0.85 | RHOA (0.38) | YAP1GPR35NOTUMKDM4ECFTR | |
| SCHEMBL17004065 | 0.85 | RHOA (0.43) | YAP1NOTUMCFTRTSHREPHX2 | |
| SCHEMBL15731227 | 0.84 | NOTUM (0.40) | YAP1GPR35NOTUMKDM4ECFTR | |
| SCHEMBL15731226 | 0.84 | NOTUM (0.40) | YAP1GPR35NOTUMKDM4ECFTR | |
| SCHEMBL13280743 | 0.83 | BTK (0.39) | YAP1NOTUMCFTRKDM1A | |
| SCHEMBL15710056 | 0.83 | BTK (0.39) | YAP1NOTUMCFTRKDM1A | |
| SCHEMBL27982605 | 0.82 | RHOA (0.36) | YAP1NOTUMCFTRTSHRMAPT | |
| SCHEMBL18830308 | 0.82 | NOTUM (0.39) | YAP1GPR35NOTUMKDM4ECFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |