Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.75 |
| ▸ | INSR | P06213 | 6/20 | 0.64 |
| ▸ | IGF1R | P08069 | 6/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | CD74 | P04233 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17410895 | 0.86 | ALK (1.00) | ALKINSRIGF1REGFRMAP4K1 | |
| SCHEMBL17410892 | 0.85 | ALK (0.85) | ALKINSRIGF1REGFRMAP4K1 | |
| SCHEMBL15444826 | 0.79 | ALK (1.00) | ALKINSRIGF1REGFRMAP4K1 | |
| SCHEMBL17411243 | 0.78 | ALK (0.82) | ALKINSRIGF1REGFRAURKA | |
| SCHEMBL11916547 | 0.77 | ALK (0.75) | ALKINSRIGF1REGFRMAP4K1 | |
| SCHEMBL17410900 | 0.76 | ALK (1.00) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL17410995 | 0.76 | ALK (0.70) | ALKINSRIGF1REGFRMET | |
| Iruplinalkib SCHEMBL17411099 | 0.76 | ALK (1.00) | ALKINSRIGF1REGFRCHEK1 | |
| Iruplinalkib SCHEMBL30297159 | 0.76 | ALK (1.00) | ALKINSRIGF1REGFRCHEK1 | |
| Iruplinalkib SCHEMBL30195062 | 0.76 | ALK (1.00) | ALKINSRIGF1REGFRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165530-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | Qilu Pharmaceutical Co., Ltd (CN) | 2017-05-10 | — | — | EP | disclosed |