Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.55 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16364235 | 0.92 | SMN1; SMN2 (0.77) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL16028832 | 0.92 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL18835260 | 0.87 | TRPC4 (0.51) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL16028428 | 0.85 | TRPC5 (0.64) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL16028333 | 0.83 | TRPC5 (0.68) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL16028066 | 0.83 | TRPC5 (0.68) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL18833614 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL16028304 | 0.83 | TRPC5 (0.70) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL16028502 | 0.82 | TRPC4 (0.57) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 | |
| SCHEMBL16028760 | 0.82 | TRPC4 (0.57) | SMN1; SMN2MAPK1L3MBTL1TRPC4TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |