Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.51 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16068298 | 0.92 | TRPC5 (0.60) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL18834471 | 0.87 | SMN1; SMN2 (0.65) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL16076223 | 0.84 | MAPT (0.53) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL16028393 | 0.81 | TRPC5 (0.66) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL19375488 | 0.81 | TRPC5 (0.67) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375019 | 0.81 | TRPC4 (0.42) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL18834872 | 0.81 | TRPC5 (0.65) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL16363982 | 0.81 | TRPC5 (0.55) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL18833941 | 0.80 | TRPC4 (0.47) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 | |
| SCHEMBL16028784 | 0.80 | TRPC5 (0.64) | TRPC4TRPC5KCNH2SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |