Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834056 | 0.83 | ALDH1A1 (0.42) | TRPC4TRPC5KCNH2ADORA3ADORA1 | |
| SCHEMBL16028103 | 0.81 | TRPC5 (0.60) | TRPC4TRPC5KCNH2ADORA3ADORA1 | |
| SCHEMBL18834408 | 0.77 | TRPC5 (0.44) | TRPC4TRPC5KCNH2ADORA3ADORA1 | |
| SCHEMBL16028034 | 0.75 | MAPT (0.63) | TRPC4TRPC5KCNH2ADORA3MAPT | |
| SCHEMBL16027733 | 0.74 | TRPC5 (0.63) | TRPC4TRPC5KCNH2ADORA3MAPT | |
| SCHEMBL16028325 | 0.74 | TRPC5 (0.61) | TRPC4TRPC5KCNH2ADORA3ADORA1 | |
| SCHEMBL16028200 | 0.73 | TRPC5 (0.60) | TRPC4TRPC5KCNH2ADORA3ADORA1 | |
| SCHEMBL16028144 | 0.73 | TRPC5 (0.57) | TRPC4TRPC5KCNH2ADORA3ADORA1 | |
| SCHEMBL16028879 | 0.72 | TRPC5 (0.72) | TRPC4TRPC5KCNH2MAPTTRPC1 | |
| SCHEMBL16028746 | 0.72 | TRPC4 (0.62) | TRPC4TRPC5KCNH2MAPTTRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |