Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 2/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14660573 | 0.85 | HRH3 (0.51) | ACHEGBA1SIGMAR1HTR1A | |
| SCHEMBL19290959 | 0.84 | MAPT (0.60) | MAPTHRH2SIGMAR1 | |
| SCHEMBL27616211 | 0.84 | MAPT (0.60) | MAPTHRH2SIGMAR1 | |
| SCHEMBL12424244 | 0.82 | ACHE (0.61) | MAPTHRH2ACHEGBA1SIGMAR1 | |
| SCHEMBL20588229 | 0.80 | ACHE (0.56) | MAPTHRH2ACHEGBA1SIGMAR1 | |
| SCHEMBL6853255 | 0.80 | ACHE (0.56) | MAPTHRH2ACHEGBA1SIGMAR1 | |
| SCHEMBL18834714 | 0.78 | MAPT (0.60) | MAPTHRH2ACHEGBA1SIGMAR1 | |
| SCHEMBL2294097 | 0.78 | MAPT (0.53) | MAPTHRH2ACHEGBA1SIGMAR1 | |
| SCHEMBL31380063 | 0.76 | MAPT (0.53) | MAPT | |
| SCHEMBL31380064 | 0.76 | MAPT (0.53) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734521-B1 | TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS | NOVARTIS AG (CH) | 2017-05-10 | — | — | EP | disclosed |