Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27616211 | 1.00 | MAPT (0.60) | MAPTHRH2SIGMAR1PDK1PDK2 | |
| SCHEMBL15275696 | 0.84 | MAPT (0.57) | MAPTHRH2SIGMAR1PDK1PDK2 | |
| SCHEMBL28053571 | 0.84 | SIGMAR1 (0.54) | MAPTSIGMAR1 | |
| SCHEMBL18834993 | 0.84 | MAPT (0.50) | MAPTHRH2SIGMAR1 | |
| SCHEMBL31751340 | 0.82 | MAPT (0.55) | MAPTHRH2SIGMAR1PDK1PDK2 | |
| SCHEMBL5372095 | 0.81 | MAPT (0.43) | MAPTSIGMAR1 | |
| SCHEMBL17069523 | 0.81 | MAPT (0.70) | MAPTHRH2SIGMAR1PDK1PDK2 | |
| SCHEMBL17426061 | 0.81 | MAPT (0.70) | MAPTHRH2SIGMAR1PDK1PDK2 | |
| SCHEMBL17069524 | 0.81 | MAPT (0.70) | MAPTHRH2SIGMAR1PDK1PDK2 | |
| SCHEMBL17426063 | 0.81 | MAPT (0.70) | MAPTHRH2SIGMAR1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964222-B1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME (US) | 2017-08-30 | — | — | EP | disclosed |