Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | UGCG | Q16739 | 11/20 | 0.49 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455122 | 0.95 | UGCG (0.51) | KMT2AUGCGCYP3A4 | |
| SCHEMBL16455068 | 0.89 | KDM1A (0.46) | KMT2AKDM1AP2RY12MAPK1 | |
| SCHEMBL16455167 | 0.88 | KDM1A (0.52) | KMT2AKDM1APOLBUGCGP2RY12 | |
| SCHEMBL16455175 | 0.88 | UGCG (0.50) | KDM1AUGCG | |
| SCHEMBL18848470 | 0.87 | HPGD (0.47) | KMT2APOLBMAPK1 | |
| SCHEMBL16455120 | 0.86 | UGCG (0.49) | KDM1AUGCGCYP3A4 | |
| SCHEMBL18848697 | 0.85 | UGCG (0.52) | KMT2AUGCGP2RY12CYP3A4 | |
| SCHEMBL16455072 | 0.83 | KDM1A (0.60) | KMT2AKDM1APOLBP2RY12 | |
| SCHEMBL16455176 | 0.82 | UGCG (0.53) | UGCGP2RY12CYP3A4 | |
| SCHEMBL16455030 | 0.79 | UGCG (0.51) | KDM1AUGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |