Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 16/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18848460 | 0.84 | KDM1A (0.52) | KDM1AKMT2AF9 | |
| SCHEMBL18848602 | 0.81 | KDM1A (0.51) | KDM1AKMT2AF9 | |
| SCHEMBL18848701 | 0.77 | KDM1A (0.50) | KDM1AKMT2AF9 | |
| SCHEMBL18848589 | 0.77 | KDM1A (0.51) | KDM1AKMT2AF9 | |
| SCHEMBL18848739 | 0.74 | KDM1A (0.51) | KDM1AF9 | |
| SCHEMBL15520031 | 0.71 | NOTUM (0.54) | F9 | |
| SCHEMBL28238886 | 0.67 | ALDH1A1 (0.46) | KDM1A | |
| SCHEMBL28237806 | 0.67 | KDM1A (0.39) | KDM1A | |
| SCHEMBL18865501 | 0.66 | KCNJ1 (0.62) | KMT2A | |
| SCHEMBL17064220 | 0.66 | CYP19A1 (0.44) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |