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SCHEMBL1884992

SCHEMBL1884992

[CH2][C@H](CNC(=O)O[C@H](OC(=O)C(C)C)C(C)C)c1ccc(Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.41
▸ L3MBTL1 Q9Y468 3/20 0.39
▸ FFAR2 O15552 1/20 0.37
▸ HPGD P15428 2/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ UTS2R Q9UKP6 1/20 0.36
▸ RAB9A P51151 2/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ POLB P06746 1/20 0.33
▸ GRIN2D O15399 1/20 0.33
▸ GRIN3B O60391 1/20 0.33
▸ GRIN1 Q05586 1/20 0.33
▸ GRIN2A Q12879 1/20 0.33
▸ GRIN2B Q13224 1/20 0.33
▸ GRIN2C Q14957 1/20 0.33
▸ GRIN3A Q8TCU5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1884778 1.00 MAPT (0.41) MAPTL3MBTL1FFAR2HPGDHSD17B10
SCHEMBL1886204 1.00 MAPT (0.41) MAPTL3MBTL1FFAR2HPGDHSD17B10
SCHEMBL1888802 1.00 MAPT (0.41) MAPTL3MBTL1FFAR2HPGDHSD17B10
SCHEMBL1891741 0.89 MAPT (0.42) MAPTL3MBTL1FFAR2HPGDHSD17B10
SCHEMBL1884906 0.89 MAPT (0.42) MAPTL3MBTL1FFAR2HPGDHSD17B10
SCHEMBL12130896 0.83 MAPT (0.39) MAPTL3MBTL1FFAR2UTS2RRAB9A
Arbaclofen Placarbil SCHEMBL351833 0.83 GABBR2 (0.47) MAPTL3MBTL1UTS2RRAB9AMEN1
Arbaclofen Placarbil SCHEMBL2472988 0.83 GABBR2 (0.47) MAPTL3MBTL1UTS2RRAB9AMEN1
Arbaclofen Placarbil SCHEMBL349961 0.83 GABBR2 (0.47) MAPTL3MBTL1UTS2RRAB9AMEN1
Arbaclofen Placarbil SCHEMBL638204 0.83 GABBR2 (0.47) MAPTL3MBTL1UTS2RRAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7935686-B2 Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use XENOPORT, INC. (US) 2011-05-03 — — US disclosed
US-20090124582-A1 Acyloxyalkyl Carbamate Prodrugs, Methods of Synthesis, and Use XENOPORT, INC. (US) 2009-05-14 — — US disclosed
US-7494985-B2 Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use XENOPORT, INC. (US) 2009-02-24 — — US disclosed
US-20060111325-A1 Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use XENOPORT, INC. 2006-05-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060111325-A1 Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use APEH, AASDHPPT, AGPS MAPT 4107/4885L3MBTL1 2410/4885FFAR2 454/4885
US-20090124582-A1 Acyloxyalkyl Carbamate Prodrugs, Methods of Synthesis, and Use APEH, AASDHPPT, AGPS MAPT 4107/4885L3MBTL1 2410/4885FFAR2 454/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.