⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470821 | 0.73 | — | — | |
| SCHEMBL12667351 | 0.68 | DAO (0.33) | — | |
| SCHEMBL9766935 | 0.67 | HTT (0.54) | — | |
| SCHEMBL13469214 | 0.65 | — | — | |
| SCHEMBL328120 | 0.64 | — | — | |
| SCHEMBL7770871 | 0.64 | — | — | |
| SCHEMBL1021705 | 0.64 | — | — | |
| SCHEMBL9767026 | 0.63 | HTT (0.50) | — | |
| SCHEMBL9767272 | 0.63 | HTT (0.50) | — | |
| SCHEMBL29303464 | 0.63 | HTT (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3790885-B1 | 1-IMIDAZOTHIADIAZOLO-2H-PYRROL-5-ONE DERIVATIVES | UCB Biopharma SRL (BE) | 2023-04-19 | — | — | EP | claimed |
| US-12116342-B2 | Method for preparing brivaracetam and intermediate thereof | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) | 2024-10-15 | — | — | US | disclosed |
| CN-115340482-B | Synthesis method of brivaracetam | 四川诺非特生物药业科技有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-112088160-B | 1-imidazothiadiazolo-2H-pyrrol-5-one derivatives | UCB生物制药有限责任公司 | 2023-07-04 | — | — | CN | disclosed |
| US-20230174478-A1 | METHOD FOR PREPARING BRIVARACETAM AND INTERMEDIATE THEREOF | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) | 2023-06-08 | — | — | US | disclosed |
| US-20220048856-A1 | METHOD FOR PREPARING BRIVARACETAM AND INTERMEDIATE THEREOF | SHANGHAI SYNCORES TECHNOLOGIES INC. LTD. (CN) | 2022-02-17 | — | — | US | disclosed |
| WO-2017076737-A1 | CONTINUOUS PROCESS FOR PREPARING BRIVARACETAM | UCB BIOPHARMA SPRL (BE) | 2017-05-11 | — | — | WO | disclosed |