Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 20/20 | 0.71 |
| ▸ | CASP8 | Q14790 | 18/20 | 0.71 |
| ▸ | CASP6 | P55212 | 17/20 | 0.71 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP9 | P55211 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18850538 | 1.00 | CASP3 (0.71) | CASP3CASP8CASP6CASP7CASP1 | |
| SCHEMBL22390725 | 0.90 | CASP3 (0.59) | CASP3CASP8CASP6CASP7 | |
| SCHEMBL22390727 | 0.90 | CASP3 (0.59) | CASP3CASP8CASP6CASP7 | |
| SCHEMBL20750671 | 0.89 | CASP3 (0.74) | CASP3CASP8CASP6 | |
| SCHEMBL20750654 | 0.85 | CASP3 (0.73) | CASP3CASP8CASP6 | |
| SCHEMBL17264153 | 0.85 | CASP3 (0.83) | CASP3CASP8CASP6CASP7 | |
| SCHEMBL18850539 | 0.84 | CASP3 (0.75) | CASP3CASP8CASP6 | |
| SCHEMBL18850553 | 0.84 | CASP3 (0.75) | CASP3CASP8CASP6 | |
| SCHEMBL17264145 | 0.83 | CASP3 (0.84) | CASP3CASP8CASP6 | |
| SCHEMBL18850557 | 0.83 | CASP3 (0.84) | CASP3CASP8CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079566-A1 | CASPASE INHIBITORS FOR USE IN THE TREATMENT OF LIVER CANCER | CONATUS PHARMACEUTICALS, INC. (US) | 2017-05-11 | — | — | WO | disclosed |