SCHEMBL17264153

SCHEMBL17264153

C[C@H](NC(=O)C(=O)Nc1c(F)cccc1F)C(=O)N[C@@H](CC(=O)O)C(=O)COc1c(F)c(F)cc(F)c1F

nearest known ligand 0.83

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 20/20 0.83
CASP6 P55212 19/20 0.83
CASP8 Q14790 19/20 0.83
CASP7 P55210 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22390638 0.91 CASP3 (0.69) CASP3CASP6CASP8CASP7
SCHEMBL22390639 0.91 CASP3 (0.69) CASP3CASP6CASP8CASP7
SCHEMBL18850541 0.91 CASP3 (1.00) CASP3CASP6CASP8CASP7
SCHEMBL22390646 0.91 CASP3 (0.69) CASP3CASP6CASP8CASP7
SCHEMBL22390658 0.90 CASP3 (0.68) CASP3CASP6CASP8CASP7
SCHEMBL22390656 0.90 CASP3 (0.68) CASP3CASP6CASP8CASP7
SCHEMBL17264147 0.90 CASP3 (1.00) CASP3CASP6CASP8
SCHEMBL22390770 0.89 CASP3 (0.66) CASP3CASP6CASP8CASP7
SCHEMBL22390763 0.87 CASP3 (0.64) CASP3CASP6CASP8CASP7
SCHEMBL22390778 0.85 CASP3 (0.62) CASP3CASP6CASP8CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022123062-A1 BLOCKING CASPASE AND/OR FASL FOR PREVENTING FATAL OUTCOME IN COVID-19 PATIENTS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2022-06-16 WO claimed
EP-3985126-B1 NON-INVASIVE DIAGNOSTIC OF NON-ALCOHOLIC STEATOHEPATITIS GENFIT (FR) 2026-03-04 EP disclosed
EP-4355915-B1 METHOD FOR NASH RISK ASSESSMENT IN PATIENTS HAVING A METABOLIC DISORDER GENFIT (FR) 2026-02-04 EP disclosed
EP-3684954-B1 NON-INVASIVE DIAGNOSTIC OF NON-ALCOHOLIC FATTY LIVER DISEASES, NON-ALCOHOLIC STEATOHEPATITIS AND/OR LIVER FIBROSIS GENFIT (FR) 2025-11-26 EP disclosed
EP-3612176-B1 COMBINATION COMPRISING THE PPAR AGONIST ELAFIBRANOR AND AN ACETYL-COA CARBOXYLASE (ACC) INHIBITOR SELECTED FROM CP-640186, GEMCABENE, GS-0976 TO TREAT INFLAMMATORY, METABOLIC, FIBROTIC OR CHOLESTATIC DISEASES GENFIT (FR) 2025-09-17 EP disclosed
EP-4541422-A2 QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS Gilead Sciences, Inc. (US) 2025-04-23 EP disclosed
CN-119462635-A Quinoline derivatives as alpha 4 beta 7 integrin inhibitors 吉利德科学公司 2025-02-18 CN disclosed
CN-119431230-A Compounds for inhibiting alpha 4 beta 7 integrin 吉利德科学公司 2025-02-14 CN disclosed
US-20250032473-A1 QUINOLINE DERIVATIVES GILEAD SCIENCES, INC. 2025-01-30 US disclosed
EP-3873900-B1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES GILEAD SCIENCES INC (US) 2025-01-08 EP disclosed
EP-3985126-A1 NON-INVASIVE DIAGNOSTIC OF NON-ALCOHOLIC STEATOHEPATITIS Genfit (FR) 2022-04-20 EP disclosed
EP-3980070-A1 METHOD FOR TREATMENT OF AT RISK PATIENTS Genfit (FR) 2022-04-13 EP disclosed
CN-114222730-A Compounds for inhibiting alpha 4 beta 7 integrins 吉利德科学公司 2022-03-22 CN disclosed
EP-3444011-A1 TREATMENT OF THE COMPLICATIONS OF CHRONIC LIVER DISEASE WITH EMRICASAN Conatus Pharmaceuticals, Inc. (US) 2019-02-20 EP disclosed
US-20190022043-A1 METHODS OF USING CASPASE INHIBITORS IN TREATMENT OF LIVER DISEASE CONATUS PHARMACEUTICALS INC (US) 2019-01-24 US disclosed
US-20170128519-A1 CASPASE INHIBITORS FOR THE TREATMENT OF COLORECTAL CANCER CONATUS PHARMACEUTICALS INC (US) 2017-05-11 US disclosed
WO-2017079566-A1 CASPASE INHIBITORS FOR USE IN THE TREATMENT OF LIVER CANCER CONATUS PHARMACEUTICALS, INC. (US) 2017-05-11 WO disclosed
US-20170100448-A1 TREATMENT OF THE COMPLICATIONS OF CHRONIC LIVER DISEASE WITH CASPASE INHIBITORS CONATUS PHARMACEUTICALS INC (US) 2017-04-13 US disclosed
US-20160213736-A1 TREATMENT OF THE COMPLICATIONS OF CHRONIC LIVER DISEASE CONATUS PHARMACEUTICALS, INC. 2016-07-28 US disclosed
WO-2015175381-A1 TREATMENT OF THE COMPLICATIONS OF CHRONIC LIVER DISEASE WITH CASPASE INHIBITORS CONATUS PHARMACEUTICALS, INC. (US) 2015-11-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190022043-A1 METHODS OF USING CASPASE INHIBITORS IN TREATMENT OF LIVER DISEASE CASP1, CASP5, CASP2 CASP3 5/4885CASP6 4/4885CASP8 11/4885
US-20170100448-A1 TREATMENT OF THE COMPLICATIONS OF CHRONIC LIVER DISEASE WITH CASPASE INHIBITORS CASP1, CASP2, CASP5 CASP3 6/4885CASP6 10/4885CASP8 8/4885
US-20170128519-A1 CASPASE INHIBITORS FOR THE TREATMENT OF COLORECTAL CANCER CASP3, CASP1, CASP7 CASP3 1/4885CASP6 6/4885CASP8 12/4885
US-20160213736-A1 TREATMENT OF THE COMPLICATIONS OF CHRONIC LIVER DISEASE CASP1, SERPINB1, CASP2 CASP3 8/4885CASP6 12/4885CASP8 15/4885
US-20250032473-A1 QUINOLINE DERIVATIVES CFTR, NQO1, IRF3 CASP3 1116/4885CASP6 1165/4885CASP8 1539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.