⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19848658 | 0.69 | MAPT (0.44) | — | |
| SCHEMBL4954067 | 0.68 | MAPT (0.35) | — | |
| SCHEMBL19911336 | 0.68 | FGFR1 (0.42) | — | |
| SCHEMBL19848148 | 0.68 | BACE1 (0.37) | — | |
| SCHEMBL27203416 | 0.67 | MAPK13 (0.34) | — | |
| SCHEMBL4059255 | 0.65 | FGFR1 (0.53) | — | |
| SCHEMBL19848517 | 0.64 | MAP4K4 (0.43) | — | |
| SCHEMBL19848089 | 0.64 | ALDH1A1 (0.58) | — | |
| Hydrochloric Acid SCHEMBL11255423 | 0.64 | TDP1 (0.52) | — | |
| SCHEMBL19911399 | 0.62 | FGFR1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932334-B2 | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-04-03 | — | — | US | disclosed |
| US-20170129883-A1 | Tetrahydroimidazopyridine Derivatives as Modulators of TNF Activity | UCB BIOPHARMA SPRL (BE) | 2017-05-11 | — | — | US | disclosed |