SCHEMBL18854271

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	GHSR	Q92847	5/20	0.56

▸	REN	P00797	2/20	0.53

▸	NMBR	P28336	2/20	0.52

▸	ECE1	P42892	5/20	0.51

▸	ACE	P12821	1/20	0.51

▸	ERAP2	Q6P179	2/20	0.50

▸	IL1RN	P18510	1/20	0.49

▸	ERAP1	Q9NZ08	1/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18854326	0.94	GHSR (0.56)	GHSRRENNMBRECE1ERAP2
SCHEMBL18854334	0.94	GHSR (0.56)	GHSRRENNMBRECE1ERAP2
SCHEMBL18862442	0.94	GHSR (0.56)	GHSRRENNMBRECE1ERAP2
SCHEMBL18862334	0.93	GHSR (0.57)	GHSRRENNMBRECE1ACE
SCHEMBL18854267	0.88	GHSR (0.55)	GHSRRENNMBRERAP2IL1RN
SCHEMBL18857368	0.88	GHSR (0.66)	GHSRERAP2
SCHEMBL18854323	0.88	GHSR (0.59)	GHSRREN
SCHEMBL22722178	0.85	GHSR (0.65)	GHSRRENNMBRECE1
SCHEMBL18854269	0.83	GHSR (0.60)	GHSRREN
SCHEMBL29426361	0.83	GHSR (0.60)	GHSRERAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20170137801-A1	TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	2017-05-18	—	—	US	disclosed