Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 15/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9938566 | 0.88 | SNCA (1.00) | SNCA | |
| SCHEMBL28656799 | 0.86 | MAPT (0.72) | SNCAGAAMAPTSMN1; SMN2MTNR1A | |
| SCHEMBL15313143 | 0.84 | SNCA (1.00) | SNCA | |
| SCHEMBL9938370 | 0.84 | SNCA (0.81) | SNCA | |
| SCHEMBL9936095 | 0.81 | CDK4 (0.78) | SNCAGAAMAPTSMN1; SMN2MTNR1A | |
| SCHEMBL15313247 | 0.81 | SNCA (1.00) | SNCA | |
| SCHEMBL15313103 | 0.80 | SNCA (1.00) | SNCA | |
| SCHEMBL25217961 | 0.79 | TRPV1 (0.67) | SNCAGAAMAPT | |
| SCHEMBL15150099 | 0.78 | MTNR1A (0.68) | SNCAGAAMAPTSMN1; SMN2MTNR1A | |
| SCHEMBL9938871 | 0.78 | SNCA (1.00) | SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651888-B1 | N-((1H-indol-3-yl)-alkyl)-4-benzyl)benzamide and N-((1H-pyrrolo[2,3-b]pyridin-3-yl)-alkyl)-4-benzyl)benzamide derivatives as alpha synuclein aggregation inhibitors for the treatment of neurodegenerative disorders | UNIV LEUVEN KATH (BE) | 2017-05-17 | — | — | EP | disclosed |