Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | RAD52 | P43351 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.45 |
| ▸ | GFER | P55789 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189132 | 0.88 | MAPT (0.59) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL29507839 | 0.88 | MAPT (0.59) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL7033209 | 0.86 | ALDH1A1 (0.49) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL27372168 | 0.83 | HTR1A (0.43) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL30879098 | 0.83 | MAPT (0.61) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL12006141 | 0.83 | MAPT (0.61) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL12006303 | 0.82 | MAPT (0.54) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL15506693 | 0.81 | MAPT (0.59) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL2017188 | 0.80 | MAPT (0.58) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL26655888 | 0.79 | KDM4E (0.54) | MAPTKDM4ERAD52ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401281-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098367-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |