Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GALK1 | P51570 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HK1 | P19367 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1173038 | 0.84 | IDO1 (0.34) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| Water SCHEMBL4797113 | 0.82 | IDO1 (0.33) | LMNASMN1; SMN2IDO1 | |
| SCHEMBL8323390 | 0.75 | CDC25B (0.33) | MEN1KMT2AMAPTKDM4EAPAF1 | |
| SCHEMBL7335323 | 0.73 | MAPT (0.39) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL29941290 | 0.70 | MEN1 (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL10977948 | 0.69 | MEN1 (0.36) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4739721 | 0.69 | KDM4E (0.33) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL21316073 | 0.69 | MEN1 (0.63) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| Isatin SCHEMBL28614049 | 0.66 | MEN1 (0.59) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| Isatin SCHEMBL31087266 | 0.66 | MEN1 (0.59) | MEN1KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296981-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-04-02 | — | — | EP | claimed |
| WO-2001087882-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | claimed |
| US-20150086504-A1 | POLYMERIC MICROEMULSIONS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-26 | — | — | US | disclosed |
| US-20110245503-A1 | ENANTIOSELECTIVE SYNTHESIS OF ASYMMETRIC BETA-CARBOLINE INTERMEDIATES | UNIVERSIDAD DE TALCA (CL) | 2011-10-06 | — | — | US | disclosed |
| US-20110112115-A1 | POLYMERIC MICROEMULSIONS | ARIEN ALBERTINA MARIA EDUARDA | 2011-05-12 | — | — | US | disclosed |
| EP-1448562-B1 | SUBSTITUTED TETRACYCLIC PYRROLOQUINOLONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO MCNEIL PHARMACEUTICAL CO (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20060034797-A1 | Polymeric micromulsions | ETHICON INC. | 2006-02-16 | — | — | US | disclosed |
| US-20050113402-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | SUI ZHIHUA (US) | 2005-05-26 | — | — | US | disclosed |
| US-6818646-B2 | 1,2,3,4-TETRAHYDRO-2-(5-(2-PYRIDINYL)-PYRIMIDIN-2-YL)-3-(2,3 -DIHYDROBENZOFURANYL)-9H-PYRROLO-(3,4-B)QUINOLIN-9-ONE; MALE ERECTILE DYSFUNCTION; SEXUAL DISORDERS | SUI ZHIHUA (US) | 2004-11-16 | — | — | US | disclosed |
| EP-1296981-B1 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1448562-A1 | SUBSTITUTED TETRACYCLIC PYRROLOQUINOLONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | Ortho-Mcneil Pharmaceutical Corp. (US) | 2004-08-25 | — | — | EP | disclosed |
| US-20040044021-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | SUI ZHIHUA (US) | 2004-03-04 | — | — | US | disclosed |
| US-6686349-B2 | ADMINISTERING TO A PATIENT FOR THE TREATMENT OF SEXUAL DYSFUNCTION AN EFFECTIVE AMOUNT OF SUBSTITUTED TETRACYCLIC PYRROLOQUINOLONE DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-02-03 | — | — | US | disclosed |
| US-6635638-B2 | Treatment of sexual dysfunction, cardiovascular system disorders | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-10-21 | — | — | US | disclosed |
| US-20030144268-A1 | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2003042213-A1 | SUBSTITUTED TETRACYCLIC PYRROLOQUINOLONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL CORPORATION (US) | 2003-05-22 | — | — | WO | disclosed |
| EP-1296981-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020010183-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-01-24 | — | — | US | disclosed |
| WO-2001087882-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113402-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | MEN1 3847/4885KMT2A 3106/4885MAPT 3888/4885 |
| US-20110245503-A1 | ENANTIOSELECTIVE SYNTHESIS OF ASYMMETRIC BETA-CARBOLINE INTERMEDIATES | PDE1B, PDE3B, PDE1A | MEN1 371/4885KMT2A 1903/4885MAPT 4704/4885 |
| US-20040044021-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | MEN1 3647/4885KMT2A 3200/4885MAPT 3924/4885 |
| US-20020010183-A1 | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | MEN1 3647/4885KMT2A 3200/4885MAPT 3924/4885 |
| US-20030144268-A1 | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | MEN1 4031/4885KMT2A 3718/4885MAPT 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.