SCHEMBL18862329

CC(C)CC(NC(=O)[C@H](CC(C)C)NC(=O)CCc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	SLC15A2	Q16348	1/20	0.51

▸	REN	P00797	10/20	0.51

▸	SLC6A5	Q9Y345	1/20	0.48

▸	ACE2	Q9BYF1	2/20	0.46

▸	HRH1	P35367	1/20	0.43

▸	CTSB	P07858	1/20	0.43

▸	CTSK	P43235	1/20	0.43

▸	ITGB2	P05107	1/20	0.43

▸	ICAM1	P05362	1/20	0.43

▸	ITGAL	P20701	1/20	0.43

▸	ERAP2	Q6P179	1/20	0.43

▸	ERAP1	Q9NZ08	1/20	0.43

▸	LNPEP	Q9UIQ6	1/20	0.43

▸	EPHX2	P34913	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18862465	0.92	SLC15A2 (0.53)	SLC15A2RENSLC6A5ACE2HRH1
SCHEMBL18862360	0.84	REN (0.52)	SLC15A2RENHRH1ERAP2ERAP1
SCHEMBL18862361	0.83	SLC15A2 (0.51)	SLC15A2RENSLC6A5ACE2HRH1
SCHEMBL18862235	0.82	REN (0.65)	RENHRH1ERAP2ERAP1LNPEP
SCHEMBL22722179	0.82	REN (0.65)	RENHRH1ERAP2ERAP1LNPEP
SCHEMBL18862365	0.82	REN (0.67)	RENHRH1ERAP2ERAP1LNPEP
SCHEMBL18857393	0.82	QPCT (0.49)	SLC6A5
SCHEMBL18857605	0.82	QPCT (0.49)	SLC6A5
SCHEMBL28410134	0.82	SLC15A2 (0.58)	SLC15A2RENSLC6A5ACE2ITGB2
SCHEMBL29351097	0.82	SLC15A2 (0.69)	SLC15A2RENSLC6A5ACE2ITGB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20170137801-A1	TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	2017-05-18	—	—	US	disclosed