Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 11/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | GRPR | P30550 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862465 | 0.91 | SLC15A2 (0.53) | SLC15A2RENSLC6A5HRH1CTSB | |
| SCHEMBL22722176 | 0.84 | REN (0.58) | SLC15A2RENSLC6A5HRH1 | |
| SCHEMBL18862329 | 0.83 | SLC15A2 (0.51) | SLC15A2RENSLC6A5HRH1CTSB | |
| SCHEMBL18862330 | 0.81 | REN (0.55) | SLC15A2RENSLC6A5HRH1 | |
| SCHEMBL20397513 | 0.80 | ITGB2 (0.50) | SLC15A2RENSLC6A5ACE2ITGB2 | |
| SCHEMBL28410134 | 0.79 | SLC15A2 (0.58) | SLC15A2RENSLC6A5ACE2ITGB2 | |
| SCHEMBL17244043 | 0.78 | SLC6A5 (0.73) | SLC15A2RENSLC6A5ITGB2ICAM1 | |
| SCHEMBL22722179 | 0.78 | REN (0.65) | RENHRH1 | |
| SCHEMBL18862365 | 0.78 | REN (0.67) | RENHRH1 | |
| SCHEMBL18862235 | 0.78 | REN (0.65) | RENHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137801-A1 | TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-05-18 | — | — | US | disclosed |