Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19887 | 0.85 | — | — | |
| SCHEMBL837076 | 0.79 | — | — | |
| SCHEMBL20535740 | 0.78 | — | — | |
| SCHEMBL7514359 | 0.78 | — | — | |
| SCHEMBL5865111 | 0.74 | CA1 (0.47) | TSHRCYP2A6MEN1ALDH1A1CYP1A2 | |
| SCHEMBL10871468 | 0.73 | CA1 (0.55) | TSHRAPPALOX12KDM4EALDH1A1 | |
| SCHEMBL7959927 | 0.71 | ALDH1A1 (0.56) | TSHRKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL1161988 | 0.67 | — | — | |
| Naphthalene SCHEMBL28380495 | 0.64 | CYP2A6 (0.67) | TSHRCYP2A6ALOX12ALDH1A1CYP1A2 | |
| Naphthalene SCHEMBL5426389 | 0.64 | CYP2A6 (0.67) | TSHRCYP2A6ALOX12ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 378 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020162345-A1 | DIBENZOPYRROMETHENE BORON CHELATE COMPOUND, NEAR-INFRARED ABSORBING MATERIAL, ORGANIC THIN FILM AND ORGANIC ELECTRONIC DEVICE | 日本化薬株式会社 | 2020-08-13 | — | — | WO | claimed |
| EP-2061450-B1 | METHODS OF MODULATING CELL PROLIFERATION AND CYST FORMATION IN POLYCYSTIC KIDNEY AND LIVER DISEASES | MEDICAL COLLEGE WISCONSIN INC (US) | 2017-04-19 | — | — | EP | claimed |
| US-20170101410-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. | 2017-04-13 | — | — | US | claimed |
| US-9440982-B2 | Substituted prolines/piperidines as orexin receptor antagonists | EOLAS THERAPEUTICS, INC. (US) | 2016-09-13 | — | — | US | claimed |
| EP-2811997-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | Eolas Therapeutics Inc. (US) | 2014-12-17 | — | — | EP | claimed |
| US-8859581-B2 | Azaheterocyclic compounds as kinase inhibitors | MERCK PATENT GMBH (DE) | 2014-10-14 | — | — | US | claimed |
| EP-1753762-B1 | LEWIS ACID MEDIATED SYNTHESIS OF CYCLIC ESTERS | METABASIS THERAPEUTICS INC (US) | 2014-03-19 | — | — | EP | claimed |
| WO-2013119639-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. (US) | 2013-08-15 | — | — | WO | claimed |
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | claimed |
| US-7687470-B2 | Avermectin and avermectin monosaccharide substituted in the 4″- and 4″ position respectively | SYNGENTA CROP PROTECTION, INC. (US) | 2010-03-30 | — | — | US | claimed |
| US-5559128-A | FOOD ANIMALS; MEDICAL DIAGNOSIS | MERCK & CO., INC. (US) | 1996-09-24 | — | — | US | claimed |
| EP-0563916-B1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-08-16 | — | — | EP | claimed |
| US-5302739-A | Chemical intermediates, herbicides | KUMIAI CHEMICAL INDUSTRY CO. (JP) | 1994-04-12 | — | — | US | claimed |
| EP-0563916-A1 | (1H-Indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, intermediates and a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-06 | — | — | EP | claimed |
| US-5242895-A | Antigrowth agents for plants | KUMIAI CHEMICAL CO. (JP) | 1993-09-07 | — | — | US | claimed |
| EP-0540612-A1 | HETEROBIFUNCTIONAL REAGENTS AND CONJUGATES WITH OXAALKYLENE UNITS FOR AMPHIPHILIC BRIDGE STRUCTURES | Pharmacia AB (SE) | 1993-05-12 | — | — | EP | claimed |
| US-5118339-A | PYRIMIDINE DERIVATIVES AND HERBICIDAL COMPOSITION CONTAINING THE SAME | KUMIAI CHEMICAL CO. (JP) | 1992-06-02 | — | — | US | claimed |
| WO-1992001474-A1 | HETEROBIFUNCTIONAL REAGENTS AND CONJUGATES WITH OXAALKYLENE UNITS FOR AMPHIPHILIC BRIDGE STRUCTURES | KABI PHARMACIA AB (SE) | 1992-02-06 | — | — | WO | claimed |
| EP-0435170-A2 | Pyrimidine or triazine derivatives and herbicidal composition containing the same | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-07-03 | — | — | EP | claimed |
| EP-0113599-B1 | PROCESS FOR THE ORGANIC SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING GALACTOSAMIN-URON-ACID MOTIVES, OLIGOSACCHARIDES OBTAINED AND THEIR BIOLOGICAL APPLICATIONS | CHOAY S.A. (FR) | 1989-02-01 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101410-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OPRL1 | TSHR 521/4885APP 133/4885CYP2A6 2520/4885 |
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TGFBR1, TGFBR2, SMAD3 | TSHR 148/4885APP 1386/4885CYP2A6 2124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.