Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY4 | P51582 | 6/20 | 0.58 |
| ▸ | P2RY2 | P41231 | 5/20 | 0.58 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.58 |
| ▸ | PGAM1 | P18669 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 2/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.48 |
| ▸ | GNG2 | P59768 | 2/20 | 0.47 |
| ▸ | GNB1 | P62873 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28322468 | 0.80 | P2RY2 (0.56) | P2RY4P2RY2PGAM1GNG2GNB1 | |
| SCHEMBL13214082 | 0.80 | P2RY4 (0.80) | P2RY4P2RY2P2RY12GNG2GNB1 | |
| SCHEMBL3033612 | 0.79 | P2RY4 (0.79) | P2RY4P2RY2P2RY12GNG2GNB1 | |
| SCHEMBL28195405 | 0.75 | P2RY4 (0.51) | P2RY4P2RY2PGAM1MEN1KMT2A | |
| SCHEMBL18867109 | 0.74 | P2RY4 (0.72) | P2RY4P2RY2P2RY12MEN1KMT2A | |
| SCHEMBL7069245 | 0.73 | MTNR1B (0.62) | MEN1KMT2AALDH1A1ALOX15MAPK1 | |
| SCHEMBL13239418 | 0.73 | MAPT (0.53) | PGAM1MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL3033611 | 0.73 | P2RY4 (1.00) | P2RY4P2RY2P2RY12P2RY6 | |
| SCHEMBL28221208 | 0.72 | PHLPP2 (0.48) | P2RY2P2RY12MEN1KMT2AGNG2 | |
| SCHEMBL1921497 | 0.69 | MEN1 (0.62) | MEN1KMT2AGAAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129653-B1 | NOVEL P2Y12 RECEPTOR ANTAGONISTS | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2017-05-17 | — | — | EP | disclosed |