SCHEMBL18868286

SCHEMBL18868286

c1ccc(-c2nc3ccccc3nc2-n2c3ccccc3c3cc4c5ccc6c7ccccc7oc6c5n(-c5ccccc5)c4cc32)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.34
HSD17B10 Q99714 1/20 0.34
PTGER1 P34995 1/20 0.32
MEN1 O00255 1/20 0.32
CSF1R P07333 1/20 0.32
PDGFRB P09619 1/20 0.32
MAPT P10636 1/20 0.32
KIT P10721 1/20 0.32
FLT3 P36888 1/20 0.32
KMT2A Q03164 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
KDM4E B2RXH2 2/20 0.32
ATM Q13315 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
HRH4 Q9H3N8 1/20 0.32
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.30
PDE10A Q9Y233 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18868298 0.96 KDM4E (0.35) CASP1HSD17B10PTGER1MEN1CSF1R
SCHEMBL18868288 0.91 L3MBTL1 (0.35) PTGER1MEN1CSF1RPDGFRBMAPT
SCHEMBL18868292 0.91 L3MBTL1 (0.35) PTGER1MEN1CSF1RPDGFRBMAPT
SCHEMBL18868289 0.90 KDM4E (0.34) HSD17B10PTGER1MEN1CSF1RPDGFRB
SCHEMBL21281830 0.89 HSD17B10 (0.40) CASP1HSD17B10PTGER1MEN1CSF1R
SCHEMBL17299652 0.89 KDM4E (0.33) CASP1HSD17B10PTGER1MEN1CSF1R
SCHEMBL17299654 0.89 KDM4E (0.33) CASP1HSD17B10PTGER1MEN1CSF1R
SCHEMBL18868269 0.86 ALDH1A1 (0.38) PTGER1MEN1CSF1RPDGFRBMAPT
SCHEMBL18868268 0.85 ALDH1A1 (0.38) PTGER1MEN1CSF1RPDGFRBMAPT
SCHEMBL18868287 0.84 ATM (0.40) PTGER1MEN1CSF1RPDGFRBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10319918-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD (KR) 2019-06-11 US disclosed
US-20170352814-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-12-07 US disclosed
US-20170352814-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-12-07 US disclosed
US-9768394-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2017-09-19 US disclosed
US-9768394-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2017-09-19 US disclosed
US-20170141326-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-05-18 US disclosed
US-20170141326-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD (KR) 2017-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10319918-B2 Organic electroluminescent compound and organic electroluminescent device comprising the same OR10J3, VDAC1, ICOSLG CASP1 949/4885HSD17B10 2649/4885PTGER1 4831/4885
US-20170352814-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME OR10J3, VDAC1, ICOSLG CASP1 949/4885HSD17B10 2649/4885PTGER1 4831/4885
US-20170141326-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME OR10J3, VDAC1, ICOSLG CASP1 949/4885HSD17B10 2649/4885PTGER1 4831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.