Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 2/20 | 0.53 |
| ▸ | KYNU | Q16719 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18868542 | 0.88 | ITGAL (0.54) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL10112626 | 0.83 | ITGAL (0.65) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL23153599 | 0.82 | ITGAL (0.64) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL18867996 | 0.81 | ITGAL (0.53) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL22296845 | 0.80 | ITGAL (0.64) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL13894422 | 0.79 | ITGAL (0.65) | ITGALITGB1ITGA5OPRK1ITGB2 | |
| SCHEMBL4926853 | 0.79 | ITGAL (0.63) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL19157785 | 0.79 | ITGAL (0.63) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL19158608 | 0.79 | ITGAL (0.62) | ITGALKYNUADRB1ADRB3ITGB1 | |
| SCHEMBL18883515 | 0.78 | ITGAL (0.61) | ITGALKYNUADRB1ADRB3ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3797775-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETIC RETINOPATHY | Novartis AG (CH) | 2021-03-31 | — | — | EP | disclosed |
| EP-3167886-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF MACULAR EDEMA | SARcode Bioscience Inc. (US) | 2017-05-17 | — | — | EP | disclosed |