Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL74359 | 0.76 | ALOX15 (0.96) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL10595737 | 0.76 | TSHR (0.61) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL10726923 | 0.74 | ALOX15 (1.00) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL5543233 | 0.74 | ALOX15 (0.59) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL75219 | 0.74 | ALOX15 (1.00) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL84546 | 0.74 | TSHR (0.59) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL734554 | 0.74 | TSHR (0.59) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL5154252 | 0.74 | ALOX15 (0.59) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL5151049 | 0.74 | RAB9A (0.59) | ALOX15TSHRCASP1RAB9AMEN1 | |
| SCHEMBL4343347 | 0.74 | ALOX15 (0.69) | ALOX15TSHRCASP1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-B1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | UNIV TEXAS (US) | 2017-05-17 | — | — | EP | disclosed |