Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19492509 | 1.00 | KCNH2 (0.41) | KCNH2GPR84NR1I2LTB4RMEN1 | |
| SCHEMBL23666479 | 0.97 | KCNH2 (0.39) | KCNH2GPR84NR1I2LTB4RMEN1 | |
| SCHEMBL23823161 | 0.94 | NR1I2 (0.42) | KCNH2GPR84NR1I2LTB4R | |
| SCHEMBL19225741 | 0.87 | NR1I2 (0.35) | KCNH2NR1I2LTB4RALDH1A1 | |
| SCHEMBL20932716 | 0.85 | GPR84 (0.47) | KCNH2GPR84MEN1ALDH1A1MAPT | |
| SCHEMBL23347114 | 0.81 | KCNH2 (0.42) | KCNH2NR1I2MAPTHTTCSNK1E | |
| SCHEMBL23347040 | 0.81 | KCNH2 (0.42) | KCNH2NR1I2MAPTHTTCSNK1E | |
| SCHEMBL18948440 | 0.81 | KCNH2 (0.42) | KCNH2NR1I2MAPTHTTCSNK1E | |
| SCHEMBL21948607 | 0.80 | KCNH2 (0.41) | KCNH2NR1I2KMT2A | |
| SCHEMBL24971835 | 0.80 | MCHR1 (0.42) | KCNH2NR1I2CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136019-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170136019-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | KCNH2 1375/4885GPR84 982/4885NR1I2 1074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.