Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRA | P18433 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266499 | 0.77 | PTPRA (0.67) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL14962122 | 0.77 | PTPRA (0.67) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL18596979 | 0.75 | PTPRA (0.56) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| Cadaverine Tartrate SCHEMBL28543828 | 0.73 | PTPRA (0.66) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| Alanine SCHEMBL28876933 | 0.73 | PTPRA (0.61) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL18596908 | 0.72 | PTPRA (0.56) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL8843877 | 0.72 | FDPS (0.60) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL10985871 | 0.72 | PTPRA (0.65) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL2684214 | 0.72 | PTPRA (1.00) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL12238431 | 0.72 | PTPRA (1.00) | PTPRACYP1A2SMN1; SMN2TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136019-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170136019-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | PTPRA 4214/4885CYP1A2 872/4885SMN1; SMN2 1246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.