Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17831326 | 0.85 | JAK2 (0.45) | SYKJAK2HDAC6MAPTLMNA | |
| SCHEMBL16012129 | 0.84 | SYK (0.44) | SYKJAK2HDAC6MAPTLMNA | |
| SCHEMBL16264855 | 0.83 | SYK (0.43) | SYKJAK2HDAC6MAPTLMNA | |
| SCHEMBL16012720 | 0.81 | PIN1 (0.58) | SYKMAPTLMNAEGFRMEN1 | |
| SCHEMBL17827716 | 0.73 | SYK (0.57) | SYKJAK2MAPTGAAMEN1 | |
| SCHEMBL18830327 | 0.72 | MAPT (0.36) | SYKMAPTLMNAEGFRITK | |
| SCHEMBL18869373 | 0.72 | SYK (0.56) | SYKJAK2MAPTGAAEGFR | |
| SCHEMBL18830586 | 0.71 | KDM4E (0.53) | SYKJAK2MAPTHTTMEN1 | |
| SCHEMBL18830184 | 0.70 | MAPT (0.49) | SYKMAPTLMNAGAAHTT | |
| SCHEMBL16245559 | 0.70 | CYSLTR2 (0.44) | SYKMAPTLMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |