Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245559 | 0.86 | CYSLTR2 (0.44) | CNR1CYSLTR2CYSLTR1PDE3BPDE3A | |
| SCHEMBL16012129 | 0.85 | SYK (0.44) | JAK2L3MBTL1CYP2C9LMNAMEN1 | |
| SCHEMBL16245555 | 0.83 | P2RX3 (0.44) | CNR1CYSLTR2CYSLTR1PDE3BPDE3A | |
| SCHEMBL16246107 | 0.82 | MEN1 (0.41) | JAK2GAASCN5APIN1MEN1 | |
| SCHEMBL16012041 | 0.81 | SYK (0.44) | JAK2MEN1KMT2A | |
| SCHEMBL17827716 | 0.80 | SYK (0.57) | JAK2GAAL3MBTL1MEN1ALDH1A1 | |
| SCHEMBL16245709 | 0.76 | RAB9A (0.51) | L3MBTL1PIN1MEN1MAPTKMT2A | |
| SCHEMBL15147773 | 0.76 | MAPT (0.53) | JAK2GAAL3MBTL1DHFRMEN1 | |
| SCHEMBL16264934 | 0.75 | RPS6KA3 (0.41) | WEE1L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL2411693 | 0.74 | AURKA (0.53) | GAAPIN1LMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |