⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29881798 | 1.00 | — | — | |
| SCHEMBL13651528 | 0.89 | — | — | |
| SCHEMBL29881025 | 0.86 | ALDH1A1 (0.50) | — | |
| SCHEMBL12663220 | 0.86 | ALDH1A1 (0.50) | — | |
| SCHEMBL1888484 | 0.86 | ALDH1A1 (0.50) | — | |
| SCHEMBL1769434 | 0.86 | ALDH1A1 (0.50) | — | |
| SCHEMBL16366589 | 0.86 | ATM (0.49) | — | |
| SCHEMBL17251234 | 0.85 | — | — | |
| SCHEMBL2706471 | 0.84 | — | — | |
| SCHEMBL20143909 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105475-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | MERXCK PATENT GESELLSCHAFT (DE) | 2011-05-05 | — | — | US | claimed |
| EP-2262785-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | Merck Patent GmbH (DE) | 2010-12-22 | — | — | EP | claimed |
| WO-2009127321-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | MERCK PATENT GMBH, (DE) | 2009-10-22 | — | — | WO | claimed |
| EP-2110374-A1 | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators | Merck Sante (FR) | 2009-10-21 | — | — | EP | claimed |
| EP-0738722-B1 | 5-Amino-benzofuran-2-carboxylic acid derivatives | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | claimed |
| CN-113214200-B | Method for preparing vilazodone intermediate through copper catalytic coupling reaction | 神隆医药（常熟）有限公司 | 2022-03-29 | — | — | CN | disclosed |
| EP-3711762-A1 | A FARNESOID X RECEPTOR AGONSITS FORUSE AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHRONIC HEPATITIS B VIRUS INFECTION | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-09-23 | — | — | EP | disclosed |
| US-10071108-B2 | Methods and pharmaceutical compositions for the treatment of hepatitis b virus infection | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2018-09-11 | — | — | US | disclosed |
| US-20180169115-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-06-21 | — | — | US | disclosed |
| US-9895380-B2 | Methods and pharmaceutical compositions for the treatment of hepatitis B virus infection | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2018-02-20 | — | — | US | disclosed |
| US-20180002305-A1 | PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES | SYMED LABS LIMITED (IN) | 2018-01-04 | — | — | US | disclosed |
| US-9796695-B2 | Process for preparing benzofuran-2-carboxamide derivatives | SYMED LABS LIMITED (IN) | 2017-10-24 | — | — | US | disclosed |
| WO-2009127321-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | MERCK PATENT GMBH, (DE) | 2009-10-22 | — | — | WO | disclosed |
| WO-2009127321-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | MERCK PATENT GMBH, (DE) | 2009-10-22 | — | — | WO | disclosed |
| EP-2110374-A1 | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators | Merck Sante (FR) | 2009-10-21 | — | — | EP | disclosed |
| EP-2110374-A1 | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators | Merck Sante (FR) | 2009-10-21 | — | — | EP | disclosed |
| US-6762300-B2 | ONE POT; SUCH AS CYCLIZATION OF 5-BROMOSALICYLALDEHYDE WITH ETHYL BROMOACETATE AND REACTING WITH FORMAMIDE THEN WITH PIPERAZINE DERIVATIVE | MERCK PATENT GMBH (DE) | 2004-07-13 | — | — | US | disclosed |
| US-20030125558-A1 | Method for producing 5-(1-piperazinyl) -benzofuran-2-carboxamide by transition metal-catalyzed amination | MERCK PATENT GMBH (DE) | 2003-07-03 | — | — | US | disclosed |
| US-5977112-A | Process of making substituted benzofurans | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5723614-A | Benzofurans | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-03 | — | — | US | disclosed |