Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838012 | 0.92 | GPR119 (0.44) | RETPIK3CDGPR119HDAC1PIK3R1 | |
| SCHEMBL30206022 | 0.85 | GPR119 (0.47) | RETPIK3CDGPR119HDAC1PARP1 | |
| SCHEMBL30206226 | 0.84 | GPR119 (0.46) | RETPIK3CDGPR119HDAC1PARP1 | |
| SCHEMBL20555810 | 0.84 | PIK3CD (0.44) | RETPIK3CDPIK3R1 | |
| SCHEMBL22772735 | 0.82 | PIK3CD (0.54) | RETPIK3CDGPR119HDAC1PIK3R1 | |
| SCHEMBL22772736 | 0.82 | PIK3CD (0.54) | RETPIK3CDGPR119HDAC1PIK3R1 | |
| SCHEMBL29353492 | 0.82 | PIK3CD (0.54) | RETPIK3CDGPR119HDAC1PIK3R1 | |
| SCHEMBL1200061 | 0.79 | GPR119 (0.61) | RETGPR119HDAC1PARP1HSD11B1 | |
| SCHEMBL1200066 | 0.79 | GPR119 (0.61) | RETGPR119HDAC1PARP1HSD11B1 | |
| SCHEMBL12740858 | 0.79 | GPR119 (0.61) | RETGPR119HDAC1PARP1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017083216-A1 | CYANOPYRIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2017-05-18 | — | — | WO | disclosed |