Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29353492 | 1.00 | PIK3CD (0.54) | PIK3CDPIK3R1RETGPR119HDAC1 | |
| SCHEMBL22772735 | 1.00 | PIK3CD (0.54) | PIK3CDPIK3R1RETGPR119HDAC1 | |
| SCHEMBL22772723 | 0.85 | PIK3CD (0.52) | PIK3CDPIK3R1 | |
| SCHEMBL22795058 | 0.83 | PIK3CD (0.79) | PIK3CDPIK3R1 | |
| SCHEMBL18870568 | 0.82 | RET (0.51) | PIK3CDPIK3R1RETGPR119HDAC1 | |
| SCHEMBL30083602 | 0.81 | RET (0.44) | PIK3CDPIK3R1RETGPR119HDAC1 | |
| SCHEMBL30083598 | 0.78 | RET (0.45) | PIK3CDPIK3R1RETGPR119HDAC1 | |
| SCHEMBL29877240 | 0.78 | GPR119 (0.57) | PIK3CDRETGPR119HDAC1PARP1 | |
| SCHEMBL24424571 | 0.77 | RET (0.46) | PIK3CDRETGPR119HDAC1PARP1 | |
| SCHEMBL22220102 | 0.77 | PARP1 (0.45) | PIK3CDRETGPR119HDAC1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3727380-B1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME LLC (US) | 2025-09-24 | — | — | EP | disclosed |
| US-11230547-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME CORP. (US) | 2022-01-25 | — | — | US | disclosed |
| US-11230547-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME CORP. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20200392144-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2020-12-17 | — | — | US | disclosed |
| US-20200392144-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392144-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3R1 58/4885RET 1758/4885 |
| US-11230547-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PI4KA | PIK3CD 1/4885PIK3R1 58/4885RET 1758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.